Pregnenolone is biochemically the mother hormone. It is made directly from cholesterol within the mitochondria of the adrenal glands.
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Pregnenolone (100 mg 100 capsules)*

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Pregnenolone 100 mg 100 capsules - LifeExtension - Nutritional Supplements, Antiaging, Health and Nutrition

Pregnenolone is biochemically a prohormone. It is made directly from cholesterol within the mitochondria of the adrenal glands and, to a lesser degree, the nervous system, with the help of the cholesterol side chain cleavage enzyme, p450scc. Pregnenolone is a precursor to various hormones, such as progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. So it can help the body maintain normal hormone levels, which in turn helps numerous body functions.

Supplement Facts

Serving Size 1 capsule

Servings Per Container 100

Amount Per Serving


100 mg

Other ingredients: rice flour, gelatin, vegetable stearate.

Contains rice. 
This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, or corn. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.

Dosage and Use
  • Take one capsule daily preferably early in the day on an empty stomach, or as recommended by a healthcare practitioner.

By Sophia Spencer - Flag 
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Updated Apr. 11, 2016, about 5 years ago

SKU: 700
UPC: 737870700104
Distributed or manufactured from Life Extension. See more Life Extension products.

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Questions and answers:

Asked on: March 15, 2013
Question: Is it safe to break this capsule in two to take 12 at a time?One doctor prescribed this brand at 100mg, my other doctor feels the dose is high.... My preg. Level is 22mg and I'm 51, 5', 105lb, w hypothyroid, adrenal fatigue and husimotos disease. I've also recently read that taking pregnenolone can lead to cancer.Please send me some feedback!Thank you!
  • A: We can only recommend taking the dose as directed by the manufacturer which is one capsule daily. Your physician may prescribe you other doses, however if 2 different doctors are telling you differently you might want to let each doctor know what the other one is saying and find out which is right for you. Cutting a capusle in half should not be a problem however your physician can advise you if that is necessary. The warnings on this product are as follows:Pregnenolone may affect levels of other hormones, such as progesterone, estrogen, testosterone and/or DHEA. Do not take this product if you have a history of seizures. Do not take this product if you have breast cancer, prostate cancer, or other hormone-sensitive diseases.

Asked on: July 6, 2013
Question: I am 64, had a total hysterectomy about 35 years ago. I've been on Permarin until Dec. of this last year. I had what the doctors thought was 2 Mimi strokes but the MRI and cat scan showed nothing but took me off the Premarin. Needless to say, my hot flashes are bad! I've been taking Pregnenolone, 50 mg along with Super Primrose, 1300 for 2 months. I think it might be helping but was wondering if I can increase to 100 mg safely? Can you help me?
  • A: The dosage on this supplement is 1 capsule which is 100mg. When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition as they cannot provide you the safety precautions you are looking for.  There are no direct warnings against taking this supplement if you have had a hysterectomy but if you have had a history of seizures it is advised not to take this type of product. 

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pregnenolone cleavage p450scc mineralocorticoids, prohormone glucocorticoids androgens biochemically, hormones lobster crustacean lifeextension
1. Statements and claims on have not been evaluated by the FDA and are not intended to treat or diagnose any ailment or disease.

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